Title of article
Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines
Author/Authors
Guo، نويسنده , , Xiaoxia and Xu، نويسنده , , Bing and Pandey، نويسنده , , Shuchita and Goessl، نويسنده , , Elisabeth and Brown، نويسنده , , James and Armesilla، نويسنده , , Angel L. and Darling، نويسنده , , John L. and Wang، نويسنده , , Weiguang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
10
From page
104
To page
113
Abstract
Most of the gemcitabine (dFdC) resistant cell lines manifested high NFκB activity. The NFκB activity can be induced by dFdC and 5-FU exposure. The chemosensitizing effect of disulfiram (DS), an anti-alcoholism drug and NFκB inhibitor, and copper (Cu) on the chemoresistant cell lines was examined. The DS/Cu complex significantly enhanced the cytotoxicity of dFdC (resistant cells: 12.2–1085-fold) and completely reversed the dFdC resistance in the resitant cell lines. The dFdC-induced NFκB activity was markedly inhibited by DS/Cu complex. The data from this study indicated that DS may be used in clinic to improve the therapeutic effect of dFdC in breast and colon cancer patients.
Keywords
Gemcitabine resistance , Disulfiram , Colorectal Cancer , breast cancer , NF?B
Journal title
Cancer Letters
Serial Year
2010
Journal title
Cancer Letters
Record number
1818397
Link To Document