Author/Authors :
Guo، نويسنده , , Xiaoxia and Xu، نويسنده , , Bing and Pandey، نويسنده , , Shuchita and Goessl، نويسنده , , Elisabeth and Brown، نويسنده , , James and Armesilla، نويسنده , , Angel L. and Darling، نويسنده , , John L. and Wang، نويسنده , , Weiguang، نويسنده ,
Abstract :
Most of the gemcitabine (dFdC) resistant cell lines manifested high NFκB activity. The NFκB activity can be induced by dFdC and 5-FU exposure. The chemosensitizing effect of disulfiram (DS), an anti-alcoholism drug and NFκB inhibitor, and copper (Cu) on the chemoresistant cell lines was examined. The DS/Cu complex significantly enhanced the cytotoxicity of dFdC (resistant cells: 12.2–1085-fold) and completely reversed the dFdC resistance in the resitant cell lines. The dFdC-induced NFκB activity was markedly inhibited by DS/Cu complex. The data from this study indicated that DS may be used in clinic to improve the therapeutic effect of dFdC in breast and colon cancer patients.
Keywords :
Gemcitabine resistance , Disulfiram , Colorectal Cancer , breast cancer , NF?B
