Author/Authors :
Chao، نويسنده , , Angel and Tsai، نويسنده , , Chia-Lung and Wei، نويسنده , , Pei-Chi and Hsueh، نويسنده , , Swei and Chao، نويسنده , , An-Shine and Wang، نويسنده , , Chin-Jung and Tsai، نويسنده , , Chi-Neu and Lee، نويسنده , , Yun-Shien and Wang، نويسنده , , Tzu-Hao and Lai، نويسنده , , Chyong-Huey Lai، نويسنده ,
Abstract :
We compared microRNA profiles between choriocarcinoma and non-cancerous trophoblasts, and revealed that miR-199b was underexpressed in choriocarcinoma. By computational prediction and microarray studies, SET (protein phosphatase 2A inhibitor) was shown to be one of the target genes regulated by miR-199b. Ectopic expression of miR-199b inhibited endogenous SET protein levels and the activity of the luciferase reporter containing the 3′-UTR of SET. Further comparisons of formalin-fixed paraffin-embedded human choriocarcinoma, mole, and non-cancer trophoblast tissues confirmed the initial findings of low miR-199b expression and SET upregulation in choriocarcinomas, suggesting that microRNA-dysregulated SET protein may account for the rapid growth seen with choriocarcinomas.
Keywords :
choriocarcinoma , Gestation , MicroRNA , MOLE , placenta
