Author/Authors :
Lima، نويسنده , , Margarida and Porto، نويسنده , , Beatriz and Rodrigues، نويسنده , , Manuel and dos Anjos Teixeira، نويسنده , , Maria and Coutinho، نويسنده , , Jorge and Ribeiro، نويسنده , , Antَnio Carlos Pinto and Malheiro، نويسنده , , Maria Isabel and Justiça، نويسنده , , Benvindo، نويسنده ,
Abstract :
A case of simultaneous presentation of B-chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is described. CLL was documented by bone marrow and peripheral blood lymphocytosis with a typical B-CLL immunophenotype. The diagnosis of AML was supported by the presence of bone marrow and circulating blast cells positive for myeloperoxidase and myeloid-associated markers. Although the immunophenotyping and morphocytochemical studies indicated two different cell populations (mature B-CLL lymphocytes and myeloblasts), chromosome aberrations commonly associated with CLL and AML were found simultaneously in the same metaphases obtained from unstimulated 24-hour cultures of peripheral blood cells.
