Author/Authors :
Takahashi، نويسنده , , Naoto and Miura، نويسنده , , Ikuo and Ohshima، نويسنده , , Atsushi and Nimura، نويسنده , , Takashi and Hashimoto، نويسنده , , Keiko and Hatano، نويسنده , , Yoshiaki and Utsumi، نويسنده , , Seiko and Kume، نويسنده , , Masaaki and Saito، نويسنده , , Kohki and Kobayashi، نويسنده , , Yoshimi and Saito، نويسنده , , Masahiro and Seto، نويسنده , , Masao and Ueda، نويسنده , , Ryuzo and Miura، نويسنده ,
Abstract :
We describe a patient with acute monocytic leukemia (M5a, FAB classification) associated with a new type of variant translocation (9;11). Southern blot analysis showed the rearrangement of the MLL (ALL-1/HRX) gene at 11q23. Fluorescence in situ hybridization (FISH) with painting probes of chromosomes 9, 11, and 22 revealed the translocation as t(9;11;22)(p22;q23;q11). This is more evidence that the production of chimeric mRNA following the translocation of the LTG9 (MLLT3/AF9) gene at 9p22 to 11q is a critical event in this leukemia subtype.
