Title of article
A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro
Author/Authors
Kawata، نويسنده , , Eri and Ashihara، نويسنده , , Eishi and Nakagawa، نويسنده , , Yoko and Kiuchi، نويسنده , , Takahiro and Ogura، نويسنده , , Mai and Yao، نويسنده , , Hisayuku and Sakai، نويسنده , , Kazuki and Tanaka، نويسنده , , Ruriko and Nagao، نويسنده , , Rina and Yokota، نويسنده , , Asumi and Takeuchi، نويسنده , , Miki and Kimura، نويسنده , , Shinya and Hirai، نويسنده , , Hideyo and Maekawa، نويسنده , , Taira، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
9
From page
245
To page
253
Abstract
Although novel agents effective against malignant mesothelioma (MM) have been developed, the prognosis of patients with MM is still poor. We generated a DNA-chimeric siRNA against polo-like kinase-1 (PLK-1), which was more stable in human serum than the non-chimeric siRNA. The chimeric PLK-1 siRNA inhibited MM cell proliferation through the induction of apoptosis. Next, we investigated the effects of zoledronic acid (ZOL) on MM cells, and found that ZOL also induced apoptosis in MM cells. Furthermore, ZOL augmented the inhibitory effects of the PLK-1 siRNA. In conclusion, combining a PLK-1 siRNA with ZOL treatment is an attractive strategy against MM.
Keywords
RNA interference , malignant mesothelioma , bisphosphonate , DNA-chimeric siRNA , PLK-1
Journal title
Cancer Letters
Serial Year
2010
Journal title
Cancer Letters
Record number
1818890
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