Author/Authors :
Kawata، نويسنده , , Eri and Ashihara، نويسنده , , Eishi and Nakagawa، نويسنده , , Yoko and Kiuchi، نويسنده , , Takahiro and Ogura، نويسنده , , Mai and Yao، نويسنده , , Hisayuku and Sakai، نويسنده , , Kazuki and Tanaka، نويسنده , , Ruriko and Nagao، نويسنده , , Rina and Yokota، نويسنده , , Asumi and Takeuchi، نويسنده , , Miki and Kimura، نويسنده , , Shinya and Hirai، نويسنده , , Hideyo and Maekawa، نويسنده , , Taira، نويسنده ,
Abstract :
Although novel agents effective against malignant mesothelioma (MM) have been developed, the prognosis of patients with MM is still poor. We generated a DNA-chimeric siRNA against polo-like kinase-1 (PLK-1), which was more stable in human serum than the non-chimeric siRNA. The chimeric PLK-1 siRNA inhibited MM cell proliferation through the induction of apoptosis. Next, we investigated the effects of zoledronic acid (ZOL) on MM cells, and found that ZOL also induced apoptosis in MM cells. Furthermore, ZOL augmented the inhibitory effects of the PLK-1 siRNA. In conclusion, combining a PLK-1 siRNA with ZOL treatment is an attractive strategy against MM.
Keywords :
RNA interference , malignant mesothelioma , bisphosphonate , DNA-chimeric siRNA , PLK-1
