Author/Authors :
Hellstrom، نويسنده , , Ingegerd and Heagerty، نويسنده , , Patrick J. and Swisher، نويسنده , , Elizabeth M. and Liu، نويسنده , , Pu and Jaffar، نويسنده , , Jade and Agnew، نويسنده , , Kathy and Hellstrom، نويسنده , , Karl Erik، نويسنده ,
Abstract :
The HE4 protein is overexpressed in ovarian carcinomas and can be detected in serum by an ELISA with sensitivity similar to CA125 and higher specificity for malignant disease. We now demonstrate that HE4 can also be detected in the urine at a specificity level of 94.4%, including 13/15 (86.6%) with stage I/II and 57/64 (89.0%) with stage III/IV disease and including 90.5% of patients with serous ovarian carcinoma. Assaying serum and urine from the same patients showed similar sensitivity. Our data indicate that measuring HE4 in urine may aid diagnosis and the monitoring of response to therapy.
Keywords :
ELISA , Ovarian cancer diagnostics , urine , HE4
