Author/Authors :
Meng، نويسنده , , Yun and He، نويسنده , , Lijie and Guo، نويسنده , , Xuegang and Tang، نويسنده , , Shanhong and Zhao، نويسنده , , Xiaodi and Du، نويسنده , , Rui-fa Jin، نويسنده , , Jiang and Bi، نويسنده , , Qian and Li، نويسنده , , Hao and Nie، نويسنده , , Yongzhan and liu، نويسنده , , Jie and Fan، نويسنده , , Daiming، نويسنده ,
Abstract :
Previous studies in our laboratory have suggested that gankyrin expression is correlated with a malignant phenotype in colorectal cancer. Here, we investigated the possible role of gankyrin in pancreatic carcinogenesis. Gankyrin expression was significantly increased in pancreatic cancer compared to non-cancerous tissues. This expression significantly enhanced cancer cell proliferation and growth in vitro and in vivo. Suppression of gankyrin downregulated cyclin A, cyclin D1, cyclin E, CDK2, CDK4, PCNA and p-Rb but upregulated p27, Rb and p53. However, gankyrin overexpression led to opposite results. Thus, gankyrin could enhance pancreatic cancer cell proliferation by promoting cell cycle progression and p53 degradation.
Keywords :
pancreatic cancer , cell cycle , Proliferation , gankyrin
