Title of article :
Bacteriophage hyaluronidase effectively inhibits growth, migration and invasion by disrupting hyaluronan-mediated Erk1/2 activation and RhoA expression in human breast carcinoma cells
Author/Authors :
Lee، نويسنده , , Joo Hyoung and Moore، نويسنده , , Lakisha D. and Kumar، نويسنده , , Sanjay and Pritchard، نويسنده , , David G. and Ponnazhagan، نويسنده , , Selvarangan and Deivanayagam، نويسنده , , Champion، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
12
From page :
238
To page :
249
Abstract :
Aberrant hyaluronan production has been implicated in many types of tumor. In this context, hyaluronidase has been explored as a viable therapeutic approach to reduce tumoral hyaluronan. However, elevated levels of hyaluronan in tumors are often associated with high expression levels of cellular hyaluronidases, which consequently produce various sizes of saturated hyaluronan fragments with divergent pro-tumoral activities. The current study shows that different hyaluronan metabolisms of mammalian and microbial hyaluronidases could elicit distinct alterations in cancer cell behavior. Unlike saturated hyaluronan metabolites, unsaturated hyaluronan oligosaccharides produced by bacteriophage hyaluronidase, HylP, had no biological effect on growth of breast carcinoma cells. More importantly, HylP’s metabolic process of hyaluronan into non-detrimental oligosaccharides significantly decreased breast cancer cell proliferation, migration and invasion by disrupting Erk1/2 activation and RhoA expression. Our results suggest that it may be possible to exploit HylP’s unique enzymatic activity in suppressing hyaluronan-mediated tumor growth and progression.
Keywords :
Hyaluronan , BtH , Hyaluronidase , breast carcinoma , HylP
Journal title :
Cancer Letters
Serial Year :
2010
Journal title :
Cancer Letters
Record number :
1819311
Link To Document :
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