Title of article
Inhibition of poly (ADP-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells
Author/Authors
Muٌoz-Gلmez، نويسنده , , J.A. and Quiles-Pérez، نويسنده , , R. and Ruiz-Extremera، نويسنده , , A. and Martيn-ءlvarez، نويسنده , , A.B. and Sanjuan-Nuٌez، نويسنده , , Laura and Carazo، نويسنده , , A. and Leَn، نويسنده , , Josefa and Oliver، نويسنده , , F.J. and Salmerَn، نويسنده , , J.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
10
From page
47
To page
56
Abstract
The purpose of this study was to investigate whether PARP-1 inhibition sensitizes human liver cancer cell lines to doxorubicin treatment. Both the addition of PARP-1 inhibitor (ANI) and depletion by means of stable siRNA significantly enhanced the growth inhibition induced by the DNA damage agents used. This effect was associated with an accumulation of unrepaired DNA, with a reduction in EGFR and Bcl-xL gene expression as well as with positive annexin-V staining. These results provide novel evidence of the direct role of PARP-1 in tumour chemoresistance in relation to its effects on the transcription of key genes involved in tumour survival.
Keywords
Antineoplastic therapy , hepatocellular carcinoma , cell death , Transcriptional regulation , DNA repair , PARP-1
Journal title
Cancer Letters
Serial Year
2011
Journal title
Cancer Letters
Record number
1819516
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