Author/Authors :
Choi، نويسنده , , Jung Eun and Hur، نويسنده , , Wonhee and Jung، نويسنده , , Chan Kwon and Piao، نويسنده , , Lian Shu and Lyoo، نويسنده , , KwangSoo and Hong، نويسنده , , Sung Woo and Kim، نويسنده , , Sung Woo and Yoon، نويسنده , , Hye-Yeon and Yoon، نويسنده , , Seung Kew Yoon، نويسنده ,
Abstract :
The 14-3-3ζ protein plays a key role in regulation of cellular processes. In the present study, we showed that 14-3-3ζ protein was significantly overexpressed in hepatoma cell lines and human tumorous tissues of hepatocellular carcinoma (HCC) patients. Knockdown with RNA interference in hepatoma cell lines with high 14-3-3ζ expression suppressed tumor cell proliferation via activation of c-Jun N-terminal kinase (JNK) and p38/MAPK. Furthermore, suppression of 14-3-3ζ enhanced the anti-cancer effect of cis-diammined dichloridoplatium (CDDP) in hepatoma cell lines. These results suggest that silencing of 14-3-3ζ may be an attractive target for HCC therapeutic development.
Keywords :
14-3-3? , Gene Therapy , hepatocellular carcinoma , Cis-diammined dichloridoplatium (CDDP) , RNA interference (RNAi)
