Author/Authors :
Charpidou، نويسنده , , Andriani and Gkiozos، نويسنده , , Ioannis K. Konstantinou، نويسنده , , Marios and Eleftheraki، نويسنده , , Anastasia and Demertzis، نويسنده , , Panagiotis and Harrington، نويسنده , , Kevin and Polyzos، نويسنده , , Aris and Syrigos، نويسنده , , Kostas N.، نويسنده ,
Abstract :
The aim of this study was to define pre-treatment VEGF, VEGFR1 and VEGFR2 levels in serum and bronchial washing samples of NSCLC patients in order to examine their correlation to survival. Forty patients with histologically confirmed NSCLC were enrolled. The results indicated that circulating VEGF was correlated to T-classification, as were the ratios of VEGF/VEGFR2 in serum and washing. Best chemotherapy response was observed at lower serum and washing VEGF concentrations. Higher VEGF levels in washing were associated with worse overall survival and progression-free survival. Similar were the results at high values of VEGF/VEGFR2 ratio in washing. Multivariate analysis revealed VEGFR2 levels in serum and washing as independent markers for overall survival. In conclusion, washing VEGFR2 levels are correlated to overall survival, whereas serum and washing VEGF levels are predictive of chemotherapy response. These could help recognize NSCLC patients who benefit from an aggressive therapeutic approach.
Keywords :
Non-small-cell lung cancer , Vascular endothelial growth factor (VEGF) , serum , washing , Prognosis , Vascular endothelial growth factor receptor (VEGFR)
