Title of article :
4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice
Author/Authors :
Guo، نويسنده , , Hua and Li، نويسنده , , Menghui and Chen، نويسنده , , Peng and Blake، نويسنده , , David J. and Kong، نويسنده , , Xiaoni and Hao، نويسنده , , Xishan and Niu، نويسنده , , Ruifang and Zhang، نويسنده , , Ning، نويسنده ,
Abstract :
Metastasis remains a formidable problem in malignant tumors. In this study, MTT assay revealed that 4-methyl-3-nitro-benzoic acid (MNBA) had no effect on cell viability and did not interfere with cell cycle in any breast cancer cell lines tested. However, treatment with MNBA on breast cancer cells can inhibit EGF-induced migration and chemotaxis in vitro. In vivo assay demonstrated that MNBA and Paclitaxel synergistically inhibited tumor growth and metastasis in breast cancer SCID mice xenografts. These results suggest that MNBA is a potent inhibitor cancer cell chemotaxis and may be developed into a novel anti-metastasis drug.
Keywords :
Cell migration inhibitor , breast cancer , Paclitaxel , metastasis
