Cytogenetic analysis of a case of myxoid liposarcoma with cartilaginous differentiation

The cytogenetic analysis of a patient with a myxoid liposarcoma exhibiting cartilaginous differentiation is presented. A complex translocation involving chromosome 12, 16, and 19 was found, instead of the t(12;16), specific for myxoid liposarcoma. The involvement of 19813 in a tumor with cartilaginous differentiation, and the assignment of TGFβ1 to 19q13.1–13.2, which appears to play a role in the formation of bone and cartilage, suggest a possible relation between both.