Author/Authors :
Hernandez، نويسنده , , Jesْs Marيa and Mecucci، نويسنده , , Cristina and Michaux، نويسنده , , Lucienne and Criel، نويسنده , , Arnold and Stul، نويسنده , , Michel and Meeus، نويسنده , , Peter and Wlodarska، نويسنده , , Iwona and Van Orshoven، نويسنده , , Angeline and Cassiman، نويسنده , , Jean-Jacques and De Wolf-Peeters، نويسنده , , Christiane and Van Den Berghe، نويسنده , , Herman، نويسنده ,
Abstract :
Twelve patients with diagnosis of B-cell non-Hodgkinʹs lymphoma/leukemia and del(7q) were studied for their clinical, cytogenetic, and molecular characteristics. Eleven patients were classified as small cell lymphoma whereas one had a diffuse large cell lymphoma. Lymphoplasmacytic features were observed in six out of eleven small cell lymphomas. Morphologically and immunologically these small cell lymphomas could be classified as chronic lymphocytic leukemia (typical or atypical; 4 cases), marginal zone lymphoma (splenic lymphoma with villous lymphocytes; 1 case), mantle cell lymphoma (2 cases), or nonspecified, non-Hodgkinʹs lymphoma (4 cases). Eleven of twelve patients presented with peripheral blood and bone marrow involvement. Two of twelve cases showed del(7q) as the sole anomaly. Two different types of deletions were present: ten cases had del(7)(q21q31) and two cases had del(7)(q31q34). Cases that could be molecularly investigated did not show any involvement of BCL2, BCL3, or BCL6, and only one case had BCL1 rearrangement. The data indicate that del(7q) is associated with a subset of mature small B-cell lymphoproliferative disorders of which some but not all show lymphoplasmatic features.
