Author/Authors :
Mueller، نويسنده , , Sabine and Yang، نويسنده , , Xiaodong and Sottero، نويسنده , , Theo L. and Gragg، نويسنده , , Ashley and Prasad، نويسنده , , Gautam and Polley، نويسنده , , Mei-Yin and Weiss، نويسنده , , William A. and Matthay، نويسنده , , Katherine K. and Davidoff، نويسنده , , Andrew M. and DuBois، نويسنده , , Steven G. and Haas-Kogan، نويسنده , , Daphne A.، نويسنده ,
Abstract :
Histone deacetylase (HDAC) inhibitors can radiosensitize cancer cells. Radiation is critical in high-risk neuroblastoma treatment, and combinations of HDAC inhibitor vorinostat and radiation are proposed for neuroblastoma trials. Therefore, we investigated radiosensitizing effects of vorinostat in neuroblastoma. Treatment of neuroblastoma cell lines decreased cell viability and resulted in additive effects with radiation. In a murine metastatic neuroblastoma in vivo model vorinostat and radiation combinations decreased tumor volumes compared to single modality. DNA repair enzyme Ku-86 was reduced in several neuroblastoma cells treated with vorinostat. Thus, vorinostat potentiates anti-neoplastic effects of radiation in neuroblastoma possibly due to down-regulation of DNA repair enzyme Ku-86.
Keywords :
radiation , Metastatic neuroblastoma , DNA repair , Vorinostat
