Author/Authors :
Miyamoto، نويسنده , , Toshihiro and Akashi، نويسنده , , Koichi and Hayashi، نويسنده , , Shin and Oogami، نويسنده , , Akiko and Okamura، نويسنده , , Takashi and Iwasaki، نويسنده , , Hiromi and Murakawa، نويسنده , , Masahiro and Harada، نويسنده , , Mine and Niho، نويسنده , , Yoshiyuki، نويسنده ,
Abstract :
We report a case of myelodysplastic syndrome with bone marrow eosinophilia and the chromosomal abnormality, inv(16)(p13q22). Hematologic findings including monocytosis and trilineage myelodysplasia were consistent with chronic myelomonocytic leukemia, and numerous abnormal eosinophils were present in the bone marrow. Chromosomal analysis of all metaphase cells from peripheral blood and bone marrow revealed inv(16)(p13q22), which is well known characteristic of acute myelomonocytic leukemia with eosinophilia (M4Eo). Both monocytes and eosinophils in this case may be derived from common leukemic progenitors affected by inv(16)(p13q22).
