Author/Authors :
Zheng، نويسنده , , Dandan and Wang، نويسنده , , Yancai and Zhang، نويسنده , , Dianrui and Liu، نويسنده , , Zhaoping and Duan، نويسنده , , Cunxian and Jia، نويسنده , , Lejiao and Wang، نويسنده , , Feihu and Liu، نويسنده , , Yue and Liu، نويسنده , , Guangpu and Hao، نويسنده , , Leilei and Zhang، نويسنده , , Qiang، نويسنده ,
Abstract :
The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosuspension could significantly enhance the in vitro cytotoxicity against PC-3 cells compared to the silybin solution. Flow cytometric (FCM) analysis demonstrated that silybin nanosuspension induced G1 cycle arrest and apoptosis in PC-3 cells. Thereby, the overall results suggest that the silybin nanosuspension represents a potential source of medicine for the treatment of human prostate cancer.
Keywords :
Nanosuspension , antitumor , cytotoxicity , Silybin
