Author/Authors :
Takata، نويسنده , , Yoshiko and Nakamoto، نويسنده , , Yasunari and Nakada، نويسنده , , Akiko and Terashima، نويسنده , , Takeshi and Arihara، نويسنده , , Fumitaka and Kitahara، نويسنده , , Masaaki and Kakinoki، نويسنده , , Kaheita and Arai، نويسنده , , Kuniaki and Yamashita، نويسنده , , Taro and Sakai، نويسنده , , Yoshio and Yamashita، نويسنده , , Tatsuya and Mizukoshi، نويسنده , , Eishiro and Kaneko، نويسنده , , Shuichi، نويسنده ,
Abstract :
The purpose of this study was to assess the properties of CD4+CD25high/low/negative T cell subsets and analyze their relation with dendritic cells (DCs) in patients with hepatocellular carcinoma (HCC). In HCC patients, the prevalence of CD45RO+ cells in CD4+CD25high T cells was increased and associated with higher frequencies of plasmacytoid DCs. Larger proportions of this T cell subset were detected in the patients with larger tumor burdens. These results suggest that increased frequencies of the CD45RO+ subset in CD4+CD25high Tregs in HCC patients may establish the immunosuppressive environment cooperatively with tolerogenic plasmacytoid DCs to promote disease progression of liver cancer.
Keywords :
Intracellular cytokine , Regulatory T cell , CD45RO , hepatocellular carcinoma , dendritic cell
