Title of article
Epstein Barr virus in relation to apoptosis markers and patients’ outcome in pediatric B-cell Non-Hodgkin lymphoma
Author/Authors
Chabay، نويسنده , , P. and Lara، نويسنده , , J. and Lorenzetti، نويسنده , , M. and Cambra، نويسنده , , P. and Acosta Haab، نويسنده , , G. and Aversa، نويسنده , , L. and De Matteo، نويسنده , , E. and Preciado، نويسنده , , M.V.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
6
From page
221
To page
226
Abstract
In this study, we investigated Epstein Barr virus (EBV) presence, associated to proliferation and apoptosis proteins in pediatric B-cell Non-Hodgkin lymphoma (B-NHL). EBERs, Ki67, active caspase 3, Bax and Bcl2 were analyzed on B-NHL tissue from 40 patients. Forty percent showed EBV expression, significantly higher among patients ⩽10 years (P = 0.027), and associated with immunosuppression (P = 0.020), but not associated apotosis markers. However, EBV was associated with a worse event-free survival (P = 0.016), particularly under immunosuppression. Even though EBV did not seem to alter apoptotic pathways, it exhibited survival disadvantage and could be an important cofactor in B-cell lymphomagenesis in younger children.
Keywords
apoptosis , Epstein Barr virus , Pediatric B-cell Non-Hodgkin lymphoma
Journal title
Cancer Letters
Serial Year
2011
Journal title
Cancer Letters
Record number
1820069
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