Author/Authors :
Tsuchiya، نويسنده , , Atsunori and Kamimura، نويسنده , , Hiroteru and Tamura، نويسنده , , Yasushi and Takamura، نويسنده , , Masaaki and Yamagiwa، نويسنده , , Satoshi and Suda، نويسنده , , Takeshi and Nomoto، نويسنده , , Minoru and Aoyagi، نويسنده , , Yutaka، نويسنده ,
Abstract :
We analyzed hepatocellular carcinoma (HCC) with progenitor cell features using hepatic stem/progenitor cell marker neural cell adhesion molecule (NCAM). Approximately 8.3% of the operated HCC cases expressed NCAM, and 22.3% of the HCC patients had soluble NCAM levels >1000 ng/ml (the “highly soluble” NCAM group). Soluble NCAM status was a significant independent factor predictive of long-term survival in patients with HCC, and high levels of soluble NCAM were significantly related to intrahepatic metastasis. The 140-kDa NCAM isoform was specifically detected in the “highly soluble” NCAM group of HCC patients and its related signals are potential drug targets for NCAM+ HCC.
Keywords :
NCAM , Soluble NCAM , HCC with progenitor features , FGFR , Intrahepatic metastasis
