Author/Authors :
Yang، نويسنده , , Yung-Ning and Chou، نويسنده , , Kai-ming and Pan، نويسنده , , Wen-Yu and Chen، نويسنده , , Yih-wen and Tsou، نويسنده , , Tsui-Chun and Yeh، نويسنده , , Ssu-Ching and Cheung، نويسنده , , Chun Hei Antonio and Chen، نويسنده , , Li-Tzong and Chang، نويسنده , , Jang-Yang، نويسنده ,
Abstract :
D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.
