Author/Authors :
He، نويسنده , , Jian-Rong and Tang، نويسنده , , Lu-Ying and Yu، نويسنده , , Dan-Dan and Su، نويسنده , , Feng-Xi and Song، نويسنده , , Er-Wei and Lin، نويسنده , , Ying and Wang، نويسنده , , Shen-Ming and Lai، نويسنده , , Guan-Chao and Chen، نويسنده , , Wei-Qing and Ren، نويسنده , , Ze-Fang، نويسنده ,
Abstract :
We investigated IgA and IgG levels against EBV viral capsid antigen (VCA) and nuclear antigen-1 (EBNA-1) in serum of 223 women with breast cancer (BC) and 309 controls in Guangzhou, China. VCA IgA levels were significantly associated with an elevated risk of BC, with adjusted ORs (95%CIs) of 1.70 (1.05–2.76) (seropositivity) and 2.21 (1.11–4.40) (unit increases in OD value). This association was stronger among young, lean, and HER2+ women. The EBNA-1 IgA levels in OD value, but not seropositivity, were associated with an increased risk of BC among ER+, PR+, and HER2+ patients. None of the IgG variables was related to BC. These results suggest the EBV association with BC in an endemic area of nasopharyngeal carcinoma.
Keywords :
breast cancer , Immunoglobulin A , immunoglobulin G , Epstein-Barr virus
