Author/Authors :
Yagyu، نويسنده , , Shigeki and Iehara، نويسنده , , Tomoko and Gotoh، نويسنده , , Takahiro and Miyachi، نويسنده , , Mitsuru and Katsumi، نويسنده , , Yoshiki and Kikuchi، نويسنده , , Ken-ichi Tsuchiya، نويسنده , , Kunihiko and Osone، نويسنده , , Shinya and Kuroda، نويسنده , , Hiroshi and Sugimoto، نويسنده , , Tohru and Sawada، نويسنده , , Tadashi and Hosoi، نويسنده , , Hajime، نويسنده ,
Abstract :
Allelic deletion of the long arm of chromosome 11 (11q loss) is closely associated with the prognosis of neuroblastoma (NB). Here we examined 11q loss using tumor-released DNA fragments in the sera of 24 cases. The allelic intensity score of a panel of polymorphic markers in 11q23 in serum DNA was significantly different between the 11q loss-positive group and the11q loss-negative group. The 11q loss-positive and -negative groups did not overlap when a cut-off value of 0.5 was chosen for the allelic intensity score. Our serum-based 11q loss analysis could predict the allelic status of 11q in tumors.
Keywords :
LOH , Serum DNA , Microsatellite analysis , 11q , Neuroblastoma
