Author/Authors :
Adeyinka، نويسنده , , Adewale and Pandis، نويسنده , , Nikos and Bardi، نويسنده , , Georgia and Bonaldi، نويسنده , , Laura and Mertens، نويسنده , , Fredrik and Mitelman، نويسنده , , Felix and Heim، نويسنده , , Sverre، نويسنده ,
Abstract :
Chromosome analysis of short-term cultured breast carcinoma cells revealed trisomy 12 in four cases. In one tumor it was the only abnormality. The second case showed cytogenetic polyclonality, but the mainline had +12 as the sole change. In the remaining two tumors, trisomy 12 was part of more complex karyotypes. These findings, especially when coupled with similar information on previously published cases, show that gain of chromosome 12 is a recurrent and sometimes early event in breast carcinogenesis.
