Author/Authors :
Callet-Bauchu، نويسنده , , Evelyne and Rimokh، نويسنده , , Ruth and Gazzo، نويسنده , , Sophie and Pagès، نويسنده , , Jacqueline and Bastion، نويسنده , , Yves G. Berger، نويسنده , , Françoise and Coeur، نويسنده , , Pierre and Felman، نويسنده , , Pascale، نويسنده ,
Abstract :
Recent evidence has shown that rare cases of aggressive non-Hodgkin lymphomas (NHL) derive from cells belonging to the natural killer (NK) lymphocyte lineage and a new clinico pathologic entity has been proposed. Though well documented in B- and T-cell NHL, chromosome abnormalities are rare findings in NK-NHL and to date, no recurrent cytogenetic abnormality has been described. The present study reports the clinical data, cytogenetic and fluorescence in situ hybridization (FISH) analysis of a new case of typical NK-NHL characterized by a primary unbalanced translocation (X;18) (q13;p11). Recent data of X;autosome translocation in malignant lymphomas have proposed Xp22 and Xq28 as the location of NHL-related oncogenes. According to other published reports on the involvement of the Xq13 region in NHL and particularly in aggressive forms, we hypothesize the existence of additional putative lymphoma-associated oncogenes at the band Xq13.
