Author/Authors :
Seol، نويسنده , , Ho Jun and Jin، نويسنده , , Juyoun and Seong، نويسنده , , Dong-Ho and Joo، نويسنده , , Kyeung Min and Kang، نويسنده , , Wonyoung and Yang، نويسنده , , Heekyoung and Kim، نويسنده , , Jandi and Shin، نويسنده , , Chul Soo and Kim، نويسنده , , YongHyun and Kim، نويسنده , , Kang Ho and Kong، نويسنده , , Doo-Sik and Lee، نويسنده , , Jung-II and Aboody، نويسنده , , Karen S. and Lee، نويسنده , , Hong Jun and Kim، نويسنده , , Seung U. and Nam، نويسنده , , Do-Hyun، نويسنده ,
Abstract :
Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain metastases located in the opposite hemisphere. The treatment also significantly decreased tumor volume in immune-deficient mice bearing MDA-MB-435 tumors when F3.CE cells were transplanted into the contralateral hemisphere. The survival rate was significantly prolonged with the treatment with F3.CE and CPT-11. This strategy may be considered as an effective treatment regimen for brain metastases.
