Author/Authors :
Acosta، نويسنده , , Sandra and Mayol، نويسنده , , Gemma and Rodrيguez، نويسنده , , Eva and Lavarino، نويسنده , , Cinzia and de Preter، نويسنده , , Katleen and Kumps، نويسنده , , Candy and Garcia، نويسنده , , Idoia and de Torres، نويسنده , , Carmen and Mora، نويسنده , , Jaume، نويسنده ,
Abstract :
Neuroblastic tumors (NBT) are composed by neuroblasts and Schwannian-like stroma. The origin of these two cell subtypes remains unclear. In this study, we describe, a neuroblastic-like subpopulation in neuroblastoma (NB) coexpressing GD2 and S100A6, neuroblastic and glial lineage markers respectively. The GD2+/S100A6+ neuroblastic subpopulation was found to be enriched in low risk NB, distributed around the perivascular niche. Some stromal bundles showed GD2+/S100A6 costaining. Metastatic bone marrow specimens also showed GD2+/S100A6+ cells. During in vitro retinoic acid induced differentiation of NB cell lines, rare GD2+/S100A6 neuroblatic cells appeared. We conclude that GD2+/S100A6+ neuroblasts may represent a tumoral glial precursor subpopulation in NBT.
Keywords :
Tumor cell origin , Glial development , Neuroblasts differentiation , Neuroblastoma , Neural crest precursor cells
