Author/Authors :
Okamura، نويسنده , , Yukiyasu and Nomoto، نويسنده , , Shuji and Hayashi، نويسنده , , Masamichi and Hishida، نويسنده , , Mitsuhiro and Nishikawa، نويسنده , , Yoko and Yamada، نويسنده , , Suguru and Fujii، نويسنده , , Tsutomu and Sugimoto، نويسنده , , Hiroyuki and Takeda، نويسنده , , Shin and Kodera، نويسنده , , Yasuhiro and Nakao، نويسنده , , Akimasa، نويسنده ,
Abstract :
In the present study, we sought to identify novel suppressor genes of hepatocellular carcinoma (HCC) using our newly designed triple-combination array. Using this method, the bleomycin hydrolase gene (BLMH) was detected as a candidate suppressor gene. We found that 28 of 48 (58.3%) tumor tissues showed BLMH promoter hypermethylation, and its expression level was significantly reduced in tumor tissues (P = 0.001). The present study suggests that our new method can detect novel genes of interest and that BLMH is a suppressor gene in HCC.
Keywords :
Bleomycin hydrolase , hepatocellular carcinoma , Expression array , Tumor suppressor gene , Single nucleotide polymorphism array , Methylation array
