Title of article
Hypoxia-inducible factors in OSCC
Author/Authors
Pérez-Sayلns، نويسنده , , Mario and Suلrez-Peٌaranda، نويسنده , , José Manuel and Pilar، نويسنده , , Gayoso-Diz and Barros-Angueira، نويسنده , , Francisco and Gلndara-Rey، نويسنده , , José Manuel and Garcيa-Garcيa، نويسنده , , Abel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
8
From page
1
To page
8
Abstract
Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe HIF basic biology and tumor cells (HIF-1α, mainly), analyzing the effects of its expression in OSCC, study its relation with other molecules such as nitric oxide (NO), carbonic anhydrase (CA) or VEGF and assess the possibility of its manipulation as a therapeutic target.
Keywords
Hypoxia-inducible factors , HIF-2? , Hypoxia , HIF-1? , Oral squamous cell carcinoma
Journal title
Cancer Letters
Serial Year
2011
Journal title
Cancer Letters
Record number
1820662
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