Author/Authors :
Ogawa، نويسنده , , Takehiko and Poncelet، نويسنده , , Dominique A and Kinoshita، نويسنده , , Yuzo and Noce، نويسنده , , Toshiaki and Takeda، نويسنده , , Mitsumasa and Kawamoto، نويسنده , , Kanji and Udagawa، نويسنده , , Koichi and Lecocq، نويسنده , , Pierre J and Marine، نويسنده , , Jean-Christophe and Martial، نويسنده , , Joseph A and Hosaka، نويسنده , , Masahiko، نويسنده ,
Abstract :
Six Krüppel-type zinc finger (ZF) genes were cloned from a seminoma cDNA library. One, ZFS-1, showed high sequence homology to the ZNF91 KMAB (Krüppel-associated box) ZF gene family and also the same chromosomal assignment. Interestingly, Northern blot analyses using ZFS-1 and ZNF91 revealed that multiple ZF genes on chromosome 19 were predominantly expressed in seminomas. In addition, the testis and the seminoma showed specific expression of 2.3 kb transcript. Our results suggest that ZF genes on chromosome 19 may be implicated in the development and/or growth of seminomas.
