Author/Authors :
Piao، نويسنده , , Lian Shu and Hur، نويسنده , , Wonhee and Kim، نويسنده , , Taek-Kyun and Hong، نويسنده , , Sung Woo and Kim، نويسنده , , Sung-Woo and Choi، نويسنده , , Jung Eun and Sung، نويسنده , , Pil Soo and Song، نويسنده , , Myeong Joon and Lee، نويسنده , , Byeong-Chel and Hwang، نويسنده , , Daehee and Yoon، نويسنده , , Seung Kew Yoon، نويسنده ,
Abstract :
CD133 is a cancer stem-cell (CSC) marker associated with radioresistance and chemoresistance in various cancers. In the present study, CD133-expressing liver cancer cells following radiation exposure showed higher activation of MAPK/PI3K signaling pathway and reduction in reactive oxygen species levels compared to CD133− cells. The in vivo study with a xenograft model showed increased tumor formation in irradiated CD133+ cell-injected nude mice compared to the CD133− group, suggesting that CD133 contributes to radioresistance in HCC. Therefore, CD133-expressing liver cancer cells have anti-apoptotic and radioresistance properties that may be useful to improve anti-cancer treatments, including chemotherapy/radiotherapy of HCC.
Keywords :
CD133 , Microarray , hepatocellular carcinoma , radioresistance , Cancer stem cell
