Title of article
Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer
Author/Authors
Liu، نويسنده , , Hanshao and Zhu، نويسنده , , Lin and Liu، نويسنده , , Bingya and Yang، نويسنده , , Liu and Meng، نويسنده , , Xianxin and Zhang، نويسنده , , Wei and Ma، نويسنده , , Yueyun and Xiao، نويسنده , , Huasheng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
8
From page
196
To page
203
Abstract
Recent studies demonstrated that in several human malignancies aberrant expression profiles of circulating microRNAs (miRNAs) anticipate great cancer diagnostic potential. Here we showed that serum miR-378 could serve as a novel noninvasive biomarker in gastric cancer (GC) detection. Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187*, miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls. Collectively, these data support our contention that serum miR-378 has strong potential as a novel noninvasive biomarker in gastric cancer detection.
Keywords
Serum microRNA , Genome-wide microRNA expression profile , Gastric cancer , Noninvasive biomarker
Journal title
Cancer Letters
Serial Year
2012
Journal title
Cancer Letters
Record number
1821032
Link To Document