Author/Authors :
Meng، نويسنده , , Songshu and Zhou، نويسنده , , Zhizhi and Chen، نويسنده , , Fei and Kong، نويسنده , , Xiangang and Liu، نويسنده , , Huairan and Jiang، نويسنده , , Ke and Liu، نويسنده , , Wenbo and Hu، نويسنده , , Maozhi and Zhang، نويسنده , , Xiaorong and Ding، نويسنده , , Chan and Wu، نويسنده , , Yantao، نويسنده ,
Abstract :
Cisplatin (DDP) is widely used in lung cancer chemotherapy. However, cisplatin resistance represents a major obstacle in effective clinical treatment. This study aims to investigate whether Newcastle disease virus (NDV) exhibits an oncolytic effect on cisplatin-resistant A549 lung cancer cells. We found that NDV induced A549/DDP cell apoptosis via the caspase pathway, particularly involving caspase-9, while the mitogen-activated protein kinase (MAPK) and Akt pathways also contributed to apoptotic induction. Furthermore, NDV displayed oncolytic effects in a mouse A549/DDP lung cancer model. Collectively, our data indicate that NDV could overcome the cisplatin resistance in lung cancer cells in vitro and in vivo.
Keywords :
Akt , Newcastle disease virus (NDV) , Cisplatin (DDP) , apoptosis , mitogen-activated protein kinase (MAPK)
