Author/Authors :
Gest، نويسنده , , Caroline and Mirshahi، نويسنده , , Pezhman and Li، نويسنده , , Hong and Pritchard، نويسنده , , Linda-Louise and Joimel، نويسنده , , Ulrich and Blot، نويسنده , , Emmanuel and Chidiac، نويسنده , , Jean and Poletto، نويسنده , , Bernard and Vannier، نويسنده , , Jean-Pierre and Varin، نويسنده , , Remi and Mirshahi، نويسنده , , Massoud and Cazin، نويسنده , , Lionel and Pujade-Lauraine، نويسنده , , Eric and Soria، نويسنده , , Jeannette and Soria، نويسنده , , Claudine، نويسنده ,
Abstract :
Seeking to improve ovarian cancer therapy, we compared biological characteristics of the moderately-aggressive OVCAR-3 cell line with two highly aggressive ovarian cancer cell populations: the SK-OV-3 cell line, and HASCJ primary cells isolated from the ascitic fluid of a patient with FIGO stage IV ovarian cancer. Secretion of angiogenic factors was not discriminative, whereas cell invasion through Matrigel and vasculogenic mimicry were much greater in the more aggressive cells. Among 10 agents tested for their ability to decrease cancer cell aggressivity using these two models, inhibitors of Stat3, IGF-IR and Rho GTPase were found to be the most promising.
Keywords :
Rho , STAT3 , Ovarian cancer , Cancer cell invasion , Vasculogenic mimicry , IGF , IGF-IR
