Author/Authors :
Armstrong، نويسنده , , Michaele J. and Stang، نويسنده , , Michael T. and Liu، نويسنده , , Jia-Ye and Gao، نويسنده , , Jinbo and Ren، نويسنده , , Baoguo and Zuckerbraun، نويسنده , , Brian S. and Mahidhara، نويسنده , , Raja S. and Xing، نويسنده , , Quanhua and Pizzoferrato، نويسنده , , Eva and Yim، نويسنده , , John H.، نويسنده ,
Abstract :
We have shown that the ectopic expression of Interferon Regulatory Factor 1 (IRF-1) results in human cancer cell death accompanied by the down-regulation of the Inhibitor of Apoptosis Protein (IAP) survivin and the induction of the cyclin-dependent kinase inhibitor p21WAF1/CIP1. In this report, we investigated the direct role of p21 in the suppression of survivin. We show that IRF-1 down-regulates cyclin B1, cdc-2, cyclin E, E2F1, Cdk2, Cdk4, and results in p21-mediated G1 cell cycle arrest. Interestingly, while p21 directly mediates G1 cell cycle arrest, IRF-1 or other IRF-1 signaling pathways may directly regulate survivin in human cancer cells.
Keywords :
Survivin , p21 , IRF-1 , CANCER , cell cycle
