Author/Authors :
Süreyya Savasan، نويسنده , , Süreyya and Lorenzana، نويسنده , , Adonis and Williams، نويسنده , , James A. and Mohamed، نويسنده , , Anwar N. and Ravindranath، نويسنده , , Yaddanapudi and Zielenska، نويسنده , , Maria and Hamre، نويسنده , , Merlin and Haas، نويسنده , , Joel E. and Rector، نويسنده , , Fredrick and Sawaf، نويسنده , , Hadi and Abella، نويسنده , , Esteban، نويسنده ,
Abstract :
Chromosomal analysis of tumor tissue from two children with alveolar rhabdomyosarcoma revealed t(1;5)(q32;q31) and t(1;22)(q21;q11.2) in all metaphases examined, respectively. Peripheral blood lymphocytes carried the same cytogenetic abnormality as that of the tumor cells in both patients. Parental lymphocytes were karyotypically normal in the patient with t(1;22), indicating a de novo constitutional translocation, but t(1;5) was paternally inherited in the other patient. The presence of constitutional translocations in these two children might have contributed to the development of alveolar rhabdomyosarcoma.
