Author/Authors :
Mo، نويسنده , , Yingxi and Midorikawa، نويسنده , , Kaoru and Zhang، نويسنده , , Zhe and Zhou، نويسنده , , Xiaoying and Ma، نويسنده , , Ning and Huang، نويسنده , , Guangwu and Hiraku، نويسنده , , Yusuke and Oikawa، نويسنده , , Shinji and Murata، نويسنده , , Mariko، نويسنده ,
Abstract :
Nasopharyngeal carcinoma (NPC) is endemic in southern China. In a genome-wide screen for genes inactivated by promoter hypermethylation, we identified Ras-related associated with diabetes (RRAD). Expression of RRAD was down-regulated in 83.3% (30/36) of the biopsies from NPC patients. RRAD was aberrantly methylated in 74.3% (26/35) of primary tumors, but not in normal nasopharyngeal epithelium. Ectopic RRAD expression in NPC cell lines inhibited the cell growth, colony formation, and cell migration. These results indicate that RRAD might act as a functional tumor suppressor and its epigenetic inactivation may play an important role in NPC development.
