Author/Authors :
Fleischman، نويسنده , , Elena W. and Reshmi، نويسنده , , Shalini and Sokova، نويسنده , , O.I. and Kirichenko، نويسنده , , O.P. and Konstantinova، نويسنده , , L.N. and Kulagina، نويسنده , , O.E. and Frenkel، نويسنده , , M.A. and Rowley، نويسنده , , Janet D.، نويسنده ,
Abstract :
We studied seven patients with various malignant hematologic disorders using fluorescence in situ hybridization (FISH) and one of these patients with spectral karyotyping (SKY). With appropriate probes, the t(8;21) and inv(16) were confirmed in two patients and the karyotypic precision was increased in five others using FISH and SKY. Two of three patients with 12p rearrangements had a deletion of one TEL allele. Thus, these newer techniques are an important adjunct to accurate chromosome analysis in malignancy.
