Author/Authors :
Marيa P. and Ladelfa، نويسنده , , Marيa Fلtima and Peche، نويسنده , , Leticia Yamila and Toledo، نويسنده , , Marيa Fernanda and Laiseca، نويسنده , , Julieta Eva and Schneider، نويسنده , , Claudio and Monte، نويسنده , , Martيn، نويسنده ,
Abstract :
Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions.
Keywords :
MAGE , Transcriptional inhibition , p53 , Anticancer therapies
