Author/Authors :
Terré، نويسنده , , C and Garcia، نويسنده , , I and Bastie، نويسنده , , J.N and Mayeur، نويسنده , , D and Decombe، نويسنده , , Nicolas Gruyer، نويسنده , , Ph and Berger، نويسنده , , R and Castaigne، نويسنده , , S، نويسنده ,
Abstract :
We report a case of chronic neutrophilic leukemia (CNL) in a 68-year-old man. Karyotype showed a clonal abnormality, never described before in CNL: 46,XY,del(11)(q23). Southern blot analysis of the MLL gene did not reveal any rearrangement, and reverse transcriptase polymerase chain reaction (RT-PCR) analysis did not show any fusion of BCR-ABL. Treatment with hydroxyurea and cytosine arabisonide was ineffective.
