Author/Authors :
Zheng، نويسنده , , Mingjie and Wang، نويسنده , , Chian-Jue and Chen، نويسنده , , Yuan-Wen and Xu، نويسنده , , Lu and Xue، نويسنده , , Dan-Dan and Fu، نويسنده , , Wei and Zhang، نويسنده , , Yi-Fen and Du، نويسنده , , Qing and Zhao، نويسنده , , Yi-Ling Ling، نويسنده , , Lijun and Ding، نويسنده , , Qiang and Liu، نويسنده , , Xiao-An and Zha، نويسنده , , Xiao-Ming and Zheng، نويسنده , , Wei and Xia، نويسنده , , Tian-Song and Wang، نويسنده , , Shui، نويسنده ,
Abstract :
Mouse models play an irreplaceable role in the in vivo research of human gastric cancer. In this study, we developed a novel human Gastric tissue-derived Orthotopic and Metastatic (GOM) mouse model of human gastric cancer, in which the human normal gastric tissues were implanted subcutaneously into immunodeficient mice to create a human gastric microenvironment. Then, human gastric cancer cells were injected into the implants. GOM model could mimic the interactions between human gastric microenvironment and human gastric cancer cells, which help exhibit the real characteristics of tumor cells, and finally mimic the clinical-like tumor proliferation and metastases of human beings.
Keywords :
Gastric cancer , metastasis , Microenvironment , Mouse model
