Author/Authors :
Mark Herbster، نويسنده , , Suellen and Ferraro، نويسنده , , Cintia Tereza Lima and Koff، نويسنده , , Natلlia Kirsch and Rossini، نويسنده , , Ana and Kruel، نويسنده , , Cleber Dario Pinto and Andreollo، نويسنده , , Nelson Adami and Rapozo، نويسنده , , Davy Carlos Mendes and Blanco، نويسنده , , Tânia Cristina Moita and Faria، نويسنده , , Paulo Antonio Silvestre de and Santos، نويسنده , , Paulo Thiago de Souza and Albano، نويسنده , , Rodolpho Matos and Simمo، نويسنده , , Tatiana de Almeida and Pinto، نويسنده , , Luis Felipe Ribeiro and Pestana، نويسنده ,
Abstract :
The role of HPV in esophageal squamous cell carcinoma (ESCCs) is controversial. Therefore, we determined, through different methodologies, the prevalence of HPV in 264 ESCC samples from Brazil, and correlated it with the presence of surrogate markers and clinicopathological characteristics. HPV is present in 13% of ESCC, and with a 3-fold variation between high and medium incidence areas. Most HPV positive tumors were infected with HPV16, but this was not associated with p16 expression, TP53 mutation status, patient age, amount of tobacco or alcohol consumption, or overall survival. We conclude that HPV infection may not have a role in ESCC.
Keywords :
CANCER , HPV , Esophagus , TP53
