Author/Authors :
Trakhtenbrot، نويسنده , , Luba and Cohen، نويسنده , , Ninette and Rosner، نويسنده , , Esther and Gipsh، نويسنده , , Nelly and Brok-Simoni، نويسنده , , Frida and Mandel، نويسنده , , Matilda and Amariglio، نويسنده , , Ninette and Rechavi، نويسنده , , Gideon، نويسنده ,
Abstract :
Spectral karyotyping (SKY) is based on the simultaneous hybridization of a set of 24 chromosome-specific DNA painting probes, each labeled with a different fluor combination. Automatic classification, based on the measurement of the spectrum for each chromosome, was applied to metaphases obtained from the affected bone marrow of a neuroblastoma case. Spectral karyotyping allowed the identification of chromosomal aberrations that could not be identified by the use of the G-banding technique, and revealed a number of gains and unbalanced translocations.
