Author/Authors :
Wang، نويسنده , , Zifeng and Yao، نويسنده , , Hong and Lin، نويسنده , , Sheng and Zhu، نويسنده , , Xiao and Shen، نويسنده , , Zan and Lu، نويسنده , , Gang and Poon، نويسنده , , Wai Sang and Xie، نويسنده , , Dan and Lin، نويسنده , , Marie Chia-mi and Kung، نويسنده , , Hsiang-fu، نويسنده ,
Abstract :
MicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular cancers. Transcriptional regulation, post-transcriptional regulation, as well as genetic alterations, are the three major mechanisms controlling the spatial and temporal expression of miRNAs. Emerging evidence now indicates that transcriptional and epigenetic regulations play major roles in miRNA expression. This review summarizes the current knowledge and discusses the future challenges.
Keywords :
Transcription machinery , Transcriptional regulation , CANCER , epigenetic regulation , miRNA
