Author/Authors :
Guillaume، نويسنده , , Beno??t and Ameye، نويسنده , , Geneviève and Libouton، نويسنده , , Jeanne-Marie and Dierlamm، نويسنده , , Judith and Vaerman، نويسنده , , Jean-Luc and Straetmans، نويسنده , , Nicole and Ferrant، نويسنده , , Augustin and Verellen-Dumoulin، نويسنده , , Christine and Michaux، نويسنده , , Lucienne، نويسنده ,
Abstract :
A case of chronic myeloid leukemia displaying an uncommon t(21;22)(q22;q11) is reported. For the first time, this translocation has been characterized by fluorescence in situ hybridization (FISH) and the reverse transcriptase polymerase chain reaction (RT-PCR). FISH, with the use of whole-chromosome painting probes and probes specific for the BCR and ABL genes, showed a three-way variant Philadelphia translocation (9;22;21)(q34;q11;q22) with a BCR/ABL fusion residing on the der(22). In addition, RT-PCR demonstrated a b2a3 BCR/ABL fusion transcript. Underlying mechanisms and prognostic implications are discussed.
