Author/Authors :
Arranz، نويسنده , , Eva and Mart??nez-Delgado، نويسنده , , Beatriz and Richart، نويسنده , , Alberto Navia-Osorio، نويسنده , , Ana and Cebri?n، نويسنده , , Arancha and Robledo، نويسنده , , Mercedes and Rivas، نويسنده , , Carmen and Ben??tez، نويسنده , , Javier، نويسنده ,
Abstract :
Comparative genomic hybridization (CGH) was used to detect chromosomal imbalances in tumor DNA from two relapsed samples obtained in stages II and IV of a T-cell non-Hodgkin lymphoma in order to identify genetic mechanisms involved in tumor progression of this neoplasm. With conventional cytogenetic techniques (CCT), a complex hyperdiploid karyotype was obtained in stage IV. Using CGH analysis, a normal profile was observed in stage II, whereas gains of 6p11.2, 7q11.2, 7q21→q32, 7q34, 10p13, Xp11.4, and loss of 4q33→qter chromosomal regions were detected in stage IV.
