Title of article
Translating TRAIL-receptor targeting agents to the clinic
Author/Authors
den Hollander، نويسنده , , Martha W. and Gietema، نويسنده , , Jourik A. and de Jong، نويسنده , , Steven and Walenkamp، نويسنده , , Annemiek M.E. and Reyners، نويسنده , , Anna K.L. and Oldenhuis، نويسنده , , Corina N.A.M. and de Vries، نويسنده , , Elisabeth G.E.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
8
From page
194
To page
201
Abstract
The extrinsic apoptotic pathway can be activated by the endogenous ligand TRAIL (Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand) by binding to the death receptors TRAIL-R1 and TRAIL-R2 on the cell surface. This pathway is currently evaluated as an anticancer treatment strategy. Both recombinant human TRAIL and several agonistic antibodies against TRAIL-R1 and R2 have been studied in single agent and combination studies and proved to be safe and well tolerated. In this article, the clinical studies published to date will be reviewed. Also, future perspectives and biomarker studies for selecting patients that will benefit from these agents will be discussed.
Keywords
Clinical studies , TRAIL , biomarkers
Journal title
Cancer Letters
Serial Year
2013
Journal title
Cancer Letters
Record number
1822625
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