Title of article :
A Novel Translocation (17;19)(p13;p13) in a Patient with Acute Myelomonocytic Leukemia
Author/Authors :
Brückner، نويسنده , , Roland and Jentsch-Ullrich، نويسنده , , Kathleen and Franke، نويسنده , , Astrid and Wieacker، نويسنده , , Peter and Stumm، نويسنده , , Markus، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
We report on a patient with acute myeloid leukemia (AML M4) and a so far unrecorded translocation (17;19). The leukemia transformed from a myeloproliferative disorder (MPD) and showed a progressive fatal course. Following transformation, all leukemic cells showed an apparently balanced translocation (17;19)(p13;p13). The breakpoint regions harbor genes such as TP53 (17p13) and E2A, ENL, or LYL1 (19p13), which could be relevant in leukemogenesis. We suspect that the translocation (17;19)(p13;p13) may be a prognostic factor for transformation from chronic MPD to acute leukemia.
Journal title :
Cancer Genetics and Cytogenetics
Journal title :
Cancer Genetics and Cytogenetics
