Sclerosing Epithelioid Fibrosarcoma: A Cytogenetic, Immunohistochemical, and Ultrastructural Study of an Unusual Histological Variant

A case of sclerosing epithelioid fibrosarcoma was studied. The tumor cells expressed vimentin, focally epithelial membrane antigen and CD34, contained cisternae of rough endoplasmic reticulum, large Golgi apparatus, many pinocytotic vesicles, and were devoid of basal lamina. Their composite karyotype was 45,Y,t(X;6)(q13;q15),t(6;13)(p11.2;q13),−22[2]/46,Y,t(X;6)(q13;q15),add(13)(p12),add(22)(q13)[3]/44∼46,der(X)t(X;6)(q13;q21),−Y,t(13;14)(q10;q10),−22,add(22)(q13)[7]/46,XY[8].