Author/Authors :
Anguita، نويسنده , , E and Barrio، نويسنده , , C.G and Gonzلlez، نويسنده , , F.A and Ferro، نويسنده , , M.T and del Potro، نويسنده , , E and Ropero، نويسنده , , P and Villegas، نويسنده , , A، نويسنده ,
Abstract :
The implication of MLL gene rearrangements in the prognosis of acute myeloblastic leukemia is an issue of considerable current interest. We report a case of a young man who initially presented with a pancytopenia and went on to develop a highly-aggressive acute myeloblastic leukemia. At this time, the karyotypic study revealed trisomy 8, a t(9;11) was demonstrated by fluorescence in situ hybridization (FISH) and the MLL/AF4 rearrangement by reverse transcriptase-polymerase chain reaction (RT-PCR).
